منابع مشابه
Redefining MicroRNA Targets
Animal microRNAs (miRNAs) guide proteins to repress the translation of target mRNAs via imperfect base pairing between the miRNA and the target. Computational analyses suggest that each miRNA regulates tens or hundreds of targets [1, 2], yet genetic studies usually show that the repression of a few targets plays a physiological role [3-5]. The extent of miRNA-mediated repression (which rarely e...
متن کاملCorrection: Human MicroRNA Targets
We incorrectly named the products of two genes, gamma actin and betaAPP, as FMRP ligands because of a misreading of Table 1 from [1]. BetaAPP is incorrectly referred to as an FMRP ligand in Tables 2 and S9, gamma actin in Table S9 only. This does not change the use of FMRP binding as a way to support the target predictions, as the statistics remain virtually the same; the enrichment of FMRP tar...
متن کاملHuman MicroRNA Targets
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted target sites on the 3' untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments. We report about 2,000 human genes with miRNA tar...
متن کاملPrediction of Microrna Targets 2
Small RNAs such as microRNAs (miRNAs) are important regulators of genes in many organisms (He and Hannon, 2004). They have also been implicated in a growing number of diseases (Dalmay and Edwards, 2006). MiRNAs are cause translational repression and potentially mRNA degradation by binding to the 3' Untranslated regions (3'UTRs) of their target genes (Giraldez et al., 2006). This binding event i...
متن کاملPrediction of Plant MicroRNA Targets
We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differentiation. The near-perfect complementarity between plant miRNAs and their targe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.03.059